Seinfeld was the bassist and vocalist for the hardcore band Biohazard. Evan was also the bassist for the short-lived supergroup Damnocracy, featured in the VH1 reality television show Supergroup, with other members including Ted Nugent, Sebastian Bach, Scott Ian and Jason Bonham.In March 2007, Evan Seinfeld debuted his new band, The Spyderz, as an opening act for a Buckcherry performance. The band was originally named White Line Fever, until it was discovered that a UK band already owned the name. The Spyderz also features guitarist John Monte, formerly of Ministry and M.O.D.. In October 2008, Seinfeld also joined Tattooed Millionaires as a bassist and co-vocalist.
In 2011 he joined Attika7, a band featuring (former) members of Walls of Jericho, Static-X, Soulfly and Possessed.
In 2011 he joined Attika7, a band featuring (former) members of Walls of Jericho, Static-X, Soulfly and Possessed.